Translation of "Klinische verschlechterung" in English

The course occasionally worsens during the first 48 hours following birth.

The incidence of clinical worsening by week 16 in patients treated with tadalafil 40 mg (5%; 4 of 79 patients) was less than placebo (16%; 13 of 82 patients).

The incidence of clinical worsening by week 16 in patients treated with tadalafil 40 mg (5 %; 4 of 79 patients) was less than placebo (16 %; 13 of 82 patients).

Therefore patients receiving Lamictal for bipolar disorder should be closely monitored for clinical worsening (including development of new symptoms) and suicidality, especially at the beginning of a course of treatment, or at the time of dose changes.

The clinical worsening is a result of local inflammatory reaction, including oedema, and manifests as a worsening of neurological symptoms including hemiparesis, ataxia, speech abnormalities, visual disturbance, cognitive/behavioural changes and seizure (dependent on the site of IRIS).

Patients (and caregivers of patients) should be alerted to the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.

All patients who were found to carry oseltamivir-resistant virus did so transiently, cleared the virus normally and showed no clinical deterioration.

If clinical deterioration of pulmonary status is evident, additional or alternative anti-pseudomonal therapy should be considered.

Time to clinical worsening was a secondary endpoint as defined as the time from randomisation to the first occurrence of a clinical worsening event (death, lung transplantation, initiation of bosentan therapy, or clinical deterioration requiring a change in epoprostenol therapy).

In the case of clinical deterioration despite Thelin treatment for at least 12 weeks, alternative therapies should be considered.

Although rare, clinical deterioration may occur at the beginning of the treatment, as has also been reported with chelating agents.

Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients who experience clinical worsening (including development of new symptoms) and/or the emergence of suicidal ideation/behaviour, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms.

If clinical deterioration of pulmonary status is evident, additional or alternative anti-pseudomonal therapy should be considered.

Collegues from Kopenhagen have reported in 2006, that in case of CF patients, who had been colonized with Achromobacter and had a clinical deterioration, specific precipitaiting antibodies could be detected in the blood.

Conclusions: In contrast to glaucoma eyes with morphological signs of deterioration1), eyes without clinical deterioration show no significant change of the HRT variables between the first and last examination after five years follow-up.

Primary endpoint was composite of in hospital death or clinical deterioration.

A clinically significant worsening of seizure frequency instead of an improvement may be observed.

However, re-treatment was performed only in those cases with angiographic findings and clinical deterioration.

Initial improvement followed by clinical deterioration and delayed reactions with rapid clinical deterioration have also been reported.

In case of clinical deterioration in spite of Revatio treatment, alternative therapies should be considered.

Patients (and caregivers of patients) should be alerted to the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.

In case of deterioration or worsening of right heart failure transfer to other medicinal products should be considered.

Immune reactivation syndrome: in HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.

Initial improvement followed by clinical deterioration and delayed reactions with rapid clinical deterioration have also been reported.

Treatment with sildenafil significantly delayed the time to clinical worsening of PAH compared to placebo (p = 0.0074).

In some patients, a worsening of more than one of the metabolic factors of weight, blood glucose and lipids was observed in clinical studies (See Section 4.4).

Immune reactivation syndrome: In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymptomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.

A smaller proportion of patients treated with ibrutinib experienced a clinically meaningful worsening of lymphoma symptoms versus temsirolimus (27% versus 52%) and time to worsening of symptoms occurred more slowly with ibrutinib versus temsirolimus (HR 0.27, p < 0.0001).

IRIS is generally suspected when patients with PML exhibit signs of clinical worsening usually, but not always, accompanied by gadolinium enhancement of PML lesions with or without mass effect on brain MRI.

The emergence of ADAwas not associated with clinical deterioration or with an increased risk of reactions to subsequent infusions in the majority of patients.

In case of meaningful clinical deterioration, further clinical evaluation or discontinuation of treatment with Galafold should be considered.

The safety profile of lamotrigine in children aged 1 month to 2 years was similar to that in older children except that clinically significant worsening of seizures ( > =50%) was reported more often in children under 2 years of age (26%) as compared to older children (14%).