Translation of "Lokale verabreichung" in English

Proportionally less active substance is required however for local administration.

Because gastrointestinal (GI) intolerance is considered to be due to local active substance administration, mg/kg or mg/m2 metrics are appropriate determinates of safety cover for this toxicity.

Toxicology studies showed that local intravenous administration and systemic exposure were well tolerated in laboratory animals (rats and cynomolgus monkeys).

The teaching of WO 83/01198 is taken up by U.S. Pat. No. 4,605,555, which also discloses the exclusively external, i.e. topical or local administration of interferon-containing gels, ointments, pastes, liquids or sprays.

A preferred use of the nucleic acid construct according to the invention consequently consists in the prophylaxis or treatment of a disease, with the invention comprising the in-vitro introduction of a nucleic acid construct into a target cell, the non-specific, virus-specific or target cell-specific, metabolically specific and/or cell cycle-specific expression of the drug in the target cell, and the local or parenteral administration of the target cell to the patient, or else the local or parenteral administration of the nucleic acid construct to the patient for in-vivo introduction of a nucleic acid construct into the target cell.

A preferred use of the novel nucleic acid construct consequently consists in the prophylaxis or treatment of a disease, with the invention comprising the in vitro insertion of a nucleic acid construct into a target cell, the nonspecific, virus-specific, target cell-specific, metabolically specific and/or cell cycle-specific expression of the drug in the target cell and the local or parenteral administration of the target cell to the patient, or else the local or parenteral administration of the nucleic acid construct to the patient for the in vivo insertion of a nucleic acid construct into the target cell.

For the production of intravaginal systems (e.g., vaginal rings) or intrauterine systems (e.g., pessaries, coils, IUDs, Mirena (R)) that are loaded with active compounds of general formula I for local administration, various polymers are suitable, such as, for example, silicon polymers, ethylene vinyl acetate, polyethylene or polypropylene.

For the production of intravaginal systems (e.g., vaginal rings) or intrauterine systems (e.g., pessaries, coils, IUDs, MIRENA (R)) that are charged with the active compounds of general formula I for local administration, various polymers, such as, for example, silicon polymers, ethylene vinyl acetate, polyethylene or polypropylene, are suitable.

Here, it is advantageous that a local administration can take place, and so systemic administrations which are a strain on the body can be avoided.

The efficient elution profile and the focused local delivery of vancomycin obtained with CERAMENT™_V is intended to prevent colonization of sensitive microorganisms, thereby protecting the bone healing, particularly in challenging cases of deep bone infection.

Moreover, as Seeger goes on to explain, the local administration of the substance would eliminate the otherwise severe side effects.

The local delivery of the stimulating serotonergic molecules by the e-dura allowed a reduction of the drug volume to one quarter compared to the study of 2012 and minimized the side effects of the substances.

Preferably, the active ingredient according to the present invention is prepared for local or systemic administration into an organism by means of the methods and auxiliary and/or additional substances known to one of ordinary skill in the art for a drug.

The local administration may, for instance, nasally or aerogenically be made on the skin, on the mucous membrane, into a body cavity, into an organ, into a joint or into the connective tissue.

Local/topical administration may be provided for by way of a liquid, spraying solution, gel, foam, cream, active patch.

Thus the present invention provides in a first aspect a pharmaceutical composition comprising a corticosteroid together with a cytokine antagonist and optionally a growth factor, wherein the cytokine antagonist is the naturally occurring or recombinant interleukin antagonist IL-1Ra protein, in particular Orthokine or Anakinra, and wherein the pharmaceutical composition is suitable for local administration.

In the second as well as the third aspect of the invention, the cytokine antagonist is the naturally occurring or recombinant interleukin antagonist IL-1Ra protein, in particular Orthokine or Anakinra, and the pharmaceutical composition is suitable for local administration.

The cytokine antagonist is the naturally occurring or recombinant interleukin antagonist IL-1Ra protein, in particular Orthokine or Anakinra, and the pharmaceutical compositions are suitable for local administration.

In the fifth as well as the sixth aspect of the invention the cytokine antagonist is the naturally occurring or recombinant interleukin antagonist IL-1Ra protein, in particular Orthokine or Anakinra, and the pharmaceutical composition is suitable for local administration.

In various patent applications and scientific publications, further potential uses of Taurolin®, for example in dental medicine and oral hygiene, in tumor diseases and in dermatology, are described, and the effect on a large number of physiological parameters by local or parenteral administration of Taurolin® solutions or taurolidin solutions was investigated.

In various patent applications and scientific publications, further potential uses of Taurolin®, for example in dental medicine and oral hygiene, in tumor diseases and in dermatology, are described, and the effect on a large number of physiological parameters by local or parenteral administration of Taurolin® solutions or taurolidin solutions was investigated.

For the production of intravaginal systems (e.g., vaginal rings) or intrauterine systems (e.g., pessaries, coils, IUDs, Mirena®) that are loaded with active compounds of general formula I? for local administration, various polymers are suitable, such as, for example, silicone polymers, ethylene vinyl acetate, polyethylene or polypropylene.

In order on the one hand to avoid local excessive concentrations on administration, but on the other hand to ensure miscibility with other components such as solutions of carbohydrates, fats, electrolytes, vitamins and trace elements without in this way exceeding the volume limit, the amino acid solution comprises 3-30% w/w protein building blocks, preferably 5-20% w/w protein building blocks and particularly preferably 7-15% w/w protein building blocks.

The medicament according to the invention can be administered by any administration route known to one skilled in the art, such as, for example, intranasally, intravenously, intramuscularly, topically and locally, preference being given to topical and local administration in the case of skin disorders.

Although the increase in the active ingredient concentration in the serum and lungs of rats after local (intratracheal) administration of moxifloxacin hydrochloride is greater than with systemic (oral) administration of the same amount of moxifloxacin hydrochloride, its concentration also falls relatively rapidly (within about an hour) to the level of the concentration reached orally, so that intratracheal local administration achieves no advantages compared with oral administration in experiments on rats too.

Interventional Oncology: Delivery of cancer-fighting agents directly to the site of a cancer tumour; currently being used mostly to treat cancers of the endocrine system, including melanoma and liver cancers.