Translation of "Saccharin sodium" in German

The active substance, glycerol and sodium saccharin dissolved in water are then added.

Subsequently, the active substance, glycerol, and sodium saccharin, dissolved in water, are added thereto.

The active substance, glycerol, and sodium saccharin, all dissolved in water, are then added.

Sweeteners, such as, for example, saccharin or the sodium salt of saccharin, can also be added.

The active ingredient, glycerol and sodium saccharin dissolved in water are then added.

Then the active ingredient, glycerin and sodium saccharin dissolved in water are added.

10.0 g of terbutaline sulfate and 2.0 g of saccharin sodium were then dissolved in this polymer solution.

Calcium carbonate Low-substituted hydroxypropyl cellulose Aluminium magnesium silicate Sodium starch glycolate (Type A) Povidone K30 Saccharin sodium Magnesium stearate Blackcurrant flavour.

Suitable sweeteners are, e.g., sodium saccharin, sodium cyclamate, sucrose, lactose, maltose, and fructose.

The other ingredients are: calcium carbonate, low substituted hydroxypropyl cellulose, aluminium magnesium silicate, sodium starch glycolate (Type A), povidone K30, saccharin sodium, magnesium stearate, blackcurrant flavour.

The other ingredients are propylene glycol, macrogol 400 (polyethylene glycol 400), d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), acesulfame potassium, saccharin sodium, sodium chloride, artificial grape bubblegum flavour, natural peppermint flavour, menthol, citric acid anhydrous, sodium citrate dihydrate, purified water.

The other ingredients are sorbitol 70% (E420), saccharin sodium, sodium citrate, citric acid anhydrous, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), propylene glycol (E1520), maltodextrin, lactic acid, glyceryl triacetate, artificial strawberry and banana flavour, purified water, sodium hydroxide and/or hydrochloric acid for pH adjustment.

Kaletra contains sodium as saccharin sodium, sodium chloride and sodium citrate, which may be harmful to people on a low sodium diet.

The other ingredients are: benzoic acid, sodium saccharin, passion fruit flavouring, sodium hydroxide, citrc acid anhydrous, water.

The other ingredients are sorbitol 70% (E420), saccharin sodium, sodium citrate, citric acid anhydrous, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), propylene glycol (E1520), maltodextrin, lactic acid, glyceryl triacetate, natural and artificial strawberry and banana flavour, purified water, sodium hydroxide and/or hydrochloric acid for pH adjustment.

Compounds of the formula IVa can be obtained for example by converting a compound of the formula IVb ##STR10## in conventional manner, for example in analogy to the formation of saccharin sodium, into a metal salt, and reacting this latter with a compound of the formula Hal--Ch2 --CO--NHR, in which "Hal" represents chlorine or bromine.

The identification threshold values cts (?mol/l) for the compounds A, E, F, and G of this invention, as well as for sodium saccharin, cyclamate, Dulcin, Aspartame, and sucrose (cane sugar) as the comparison compounds, are compiled in Table 2.

According to these results, the LD50 after a one-time intraperitoneal administration of sodium saccharin and of compound A is approximately at 6.0 g/kg body weight.

The European patent application published under number EP 0 340 662 describes a solid drug containing N-acetylcysteine in granular form, which contains lignite as a taste-enhancer, bihydratized saccharin sodium, beta carotene and flavorings.

1 kg of sodium carboxymethyl starch, 0.3 kg of highly disperse silica, 3 kg of xylitol, 50 g of saccharin sodium, 50 g of peppermint,-flavoring and 0.1 kg of magnesium stearate are admixed to the screened granules.

For medical use the compounds according to the invention may be incorporated, with the aid of conventional galenic excipients such as lactose, manitol, corn starch, methyl cellulose, hydroxyethyl cellulose, polyethylene oxide, highly dispersed aluminium oxide, magnesium-aluminium silicate, magnesium oxide, magnesium stearate, sodium lauryl sulphate, sodium citrate, tartaric acid, sodium pyrosulphite, dioctylsodiumsulfosuccinate, sodium salt of methyl p-hydroxybenzoate, sodium salt of propyl p-hydroxybenzoate, sodium saccharin, flavourings and antifoamers into conventional galenic preparations such as tablets, film-coated tablets, oblong tablets, coated tablets or capsules and the delayed release forms thereof, ampoules, dry ampoules, dry granules or dry elixirs.

For determining the sweetening power, an aqueous 5% (g/v) (% g/v is the number of grams of agent in 100 ml of solution) sucrose solution was compared with aqueous solutions of the sodium salt of 3-(3-carbamoyl-2,4,6-tribromophenyl)propionic acid (A) as well as sodium saccharin and sodium cyclamate in up to eight concentration stages with the use of taste tests.

Insofar as its practical utilization as a substitute compound for sodium saccharin, this good compatibility of compound A, which here can be estimated only roughly, must be considered to be very advantageous since it will probably be possible to make do with one-tenth of the sodium saccharin dose due to the very high sweetening power of the sweeteners of formula I according to this invention.

A solution of 7.5 g of 2-bromo-N-(4-oxo-1-benzopyran-3-yl)-acetamide and 5.5 g of saccharin sodium in 100 ml of absolute dimethyl formamide is heated for 5 hours to 100° C., then cooled to room temperature.