Translation of "Point mutation" in German

Commonly used substitution matrices include the blocks substitution (BLOSUM) and point accepted mutation (PAM) matrices.

It is a point genetic mutation of Pinot noir.

This point mutation involves the noncoding regulatory area of the Factor II gene (prothrombin).

The SOE-PCR for the generating a point mutation is performed in several steps.

Variants according to the invention may therefore be stabilized additionally to oxidation particularly by this point mutation.

A type of point mutation caused by the replacement of one nucleotide for another.

Often, these functions are lost due to a single point mutation.

A single point mutation in the Thr956 of GRIP1 in transgenic mice impairs dendritic development.

The introduction of a point mutation replacing Asp194 prima facie impedes the formation or stability of the catalytic conformation of serine proteases.

This second mutational event might be the activation of Ras by a point mutation.

The introduction of a point mutation replacing Asp194 prima facie impedes the formation or respectively the stability of the catalytic confirmation of serine proteases.

The disease is caused by point mutation c.986T > C in KCNJ10 gene.

The bacterial reverse mutation test is commonly employed as an initial screen for genotoxic activity and, in particular, for point mutation-inducing activity.

But every now and then, a point mutation disrupts an important capability in a cell or causes a cell to misbehave in harmful ways.

If the structural alteration is small and results in the deletion of one or a few genes the net effect can be difficult to distinguish from a point mutation.

The cDNA insert is flanked at its 5' end by a stretchof about 20-25 deoxyguanosine residues and shows a point mutation at position 153, converting a C to a T residue without affecting the resulting amino acid.

All the clones have a point mutation (A?G transition) here, but this does not lead to a change in the corresponding amino acid (glutamine).

With recessive diseases, it is often important to evaluate whether a particular point mutation occurs only on one allele or on both alleles simultaneously (see cystic fibrosis with more than 30 mutations described to date).

To efficiently express the retroviral sequences, thus TTTTTNT signals possibly present in the retroviral sequences or in the foreign gene, respectively, should be modified by point mutation without changing the amino acid context of the retroviral proteins or destroying the controlling signals on the RNA genome of the defective retroviruses, such as e.g. psi, and the integration region “att”.

Apart from the fact that this is a cumbersome procedure, for each mutation that does not already produce an RFLP, it is necessary that a design for a primer adjacent to the point mutation be possible which should allow digestion with a restriction enzyme that cleaves exactly at the given site.

A mutation according to the invention is meant to be a point mutation, a mutation affecting several nucleotides, a deletion, an addition, or an exchange of nucleotides.

Such properties of alanine-containing peptide chains have recently been demonstrated by point mutation (exchange of proline for alanine) (Dodge & Scheraga, 1996).