Übersetzung für "Fasting conditions" in Deutsch

Moderate fat diet is similar to bioavailability under fasting conditions.

This range of fluctuation encompasses blood glucose concentrations under fasting conditions, postprandial conditions, and postabsorptive conditions.

When isotretinoin is taken with food, the bioavailability is doubled relative to fasting conditions.

The CHMP concluded that bioequivalence has not been demonstrated in fasting conditions.

The grounds for the referral were that the bioequivalence studies had only been performed under fasting conditions.

The pharmacokinetics of indinavir taken as indinavir sulphate salt (from opened hard capsules) mixed in apple sauce were generally comparable to the pharmacokinetics of indinavir taken as hard capsules, under fasting conditions.

Other risk factors for lactic acidosis are excessive alcohol intake, hepatic impairment, inadequately controlled diabetes, ketosis, prolonged fasting and any conditions associated with hypoxia, as well as concomitant use of medicinal products that may cause lactic acidosis (see sections 4.3 and 4.5).

Therefore, it is expected that similar results would be obtained in studies under fed conditions with the lower strengths as it was obtained in the studies under fasting conditions for these strengths.

Based on the discussion above, it is considered reasonable to look at the immediate release phase separately, and fasting conditions is considered more sensitive in relation to detect difference between test and reference for a highly soluble immediate release formulation in order to provide proof of bioequivalence.

Moreover, it appears that the prolonged release part of the formulation is not significantly affected by food, which is confirmed by the similar results obtained in the studies with the 54 mg strength in fasting and fed conditions, respectively, for both the test and reference product.

After adjustment of the strength, the film-coated tablet formulation (360 mg strength) was equivalent to deferasirox dispersible tablets (500 mg strength) with respect to the mean area under the plasma concentration time curve (AUC) under fasting conditions.

At the time of the initial authorisation, bioequivalence was shown under fasting conditions (study No 237/00).

The time to tedizolid peak concentration with oral administration under fasting conditions is 6 hours faster than when administered with a high-fat, high-calorie meal (see section 5.2).

Other risk factors for lactic acidosis are excessive alcohol intake, hepatic insufficiency, inadequately controlled diabetes, ketosis, prolonged fasting, and any conditions associated with hypoxia, as well as concomitant use of medicinal products that may cause lactic acidosis (see sections 4.3 and 4.5).

The CHMP assessed the open label, randomized, comparative bioavailability study of glimepiride 1 mg tablets under fasting conditions and the Applicant justifications for the design of the study.

For metformin, AUC decreased by 12% and Cmax decreased by 26% compared to fasting conditions.

Relative to fasting conditions, the administration of a single dose of Vemlidy with a high fat meal resulted in a 65% increase in tenofovir alafenamide exposure.

Relative to fasting conditions, the administration of tenofovir alafenamide with a high fat meal (~800 kcal, 50% fat) resulted in a decrease in tenofovir alafenamide Cmax (15-37%) and an increase in AUClast (17-77%).

In a food effect study, lurasidone mean Cmax and AUC increased approximately by 2-3-times and 1.5-2-times, respectively, when administered with food compared to the levels observed under fasting conditions.