Translation of "Tumor type" in German

Here, the general condition, age, tumor type and tumor size play a role.

In the final population PK model, in addition to primary tumor type, body-weight, serum aspartate aminotransferase and albumin were identified as a statistically significant covariates affecting the exposure of trastuzumab.

Tumor type P 388 (leukaemia) was induced i.p. in mice (106 cells/mouse) in accordance with procedure 1200 (page 91c).

The animals are vaccinated against the wild-type tumor by administration of hybrid tumor cells, but an immunization against a specific tumor antigen with a defined molecule is impossible.

By this the efficacy of the pharmaceutical composition may be adjusted advantageously with respect to the tumor type and/or size to be treated.

Depending on the tumor type, its parameters, and the stage of the disease, our patients are examined regularly (clinically and partly also with imaging procedures such as CT/MRI, sonography, or X-rays).

Methods: Ten enucleated globes with the histopathologically and immunohistochemically (S-100, HMB-45, PNL-2, Melan-A) confirmed diagnosis of a malignant melanoma of the ciliary body with extraocular extension were matched with ten globes with a ciliary body melanoma without extraocular extension regarding tumor size, cell type and melanin content.

But that is in the nature of the matter: For each combination of tumor type and cytostatics or radiation, a separate study would be needed to conduct.

As with all immatics' vaccines, IMA910 has been designed to elicit a strong, clinically relevant immune response to a specific tumor type.

As with all immatics’ vaccines, IMA901 has been designed to elicit a strong, clinically relevant immune response to a specific tumor type.

Therapy consists of surgical removal of the tumor, since this type shows little response to chemotherapy or radiotherapy.

The method as claimed in claim 12, wherein receptor R 1 is an antibody which specifically binds to pyruvate kinase isoenzyme of the tumor M2-PK type and discriminates between other pyruvate kinase isoenzymes.

In particular, the present invention concerns a method for the selective, qualitative or/and quantitative detection of the pyruvate kinase isoenzyme of the type tumor M2 (tumor M2-PK) which serves as a tumor marker, in human and animal feces for detecting a malignant process in the gastrointestinal tract and the abdominal cavity (oesophagus, stomach, small intestine, pancreas and large intestine) and a test kit for carrying out the method.

Isoenzymes of carbohydrate metabolism, in particular pyruvate kinase isoenzymes and above all pyruvate kinase, in particular, of the type tumor M2-PK appear to be such indicators.

In this case the primary antibody (the so-called catcher) is immobilized on a piezoelectric substrate and a change in the oscillating frequency of the quartz crystal is measured after binding to the pyruvate kinase isoenzyme of the type tumor M2-PK to be analysed.

Up to now this qualitative and quantitative detection of pyruvate kinase of the type tumor M2 (tumor M2-PK) in serum or plasma has been carried out by means of an ELISA as described among others in EP 0 444 118.

Particularly preferred, the invention relates to a method for the selective qualitative or/and quantitative detection of the pyruvate kinase isoenzyme of the type tumor M2 (tumor M2-PK) which serves as a tumor marker, in human and animal feces for detecting a malignant process in the gastrointestinal tract which is characterized in that the tumor M2-PK is determined in a stool specimen by an immunoassay technique with the aid of at least one antibody which specifically binds tumor M2-PK and does not cross-react with any other pyruvate kinase isoenzyme.

This method may result in successful growth rates of 50% or sometimes even more for the transplanted tumor tissue, but, depending on the tumor type and properties, it takes several weeks or even months before in-vivo cell proliferation begins.