Übersetzung für "Type i diabetes" in Deutsch

There is only limited experience in the treatment of - patients with DME due to type I diabetes.

Type I diabetes is characterized by the pancreas making too little or no insulin.

Juvenile (type I) diabetes results from the destruction of insulin-producing cells in the pancreas.

The oligomerized complex can be preferably used as a diagnostic or therapeutic reagent in type I diabetes.

No one knows exactly what causes them, but these disorders sabotage the immune system to varying degrees, and underlie problems like arthritis, Type I diabetes, and multiple sclerosis.

There is only limited experience in the treatment of subjects with DME due to type I diabetes or in diabetic patients with an HbA1c over 12% or with proliferative diabetic retinopathy.

Immune-mediated or autoimmune conditions such as type I diabetes, colitis, autoimmune thyroiditis, pancreatitis, glomerulonephritis, among other, were reported in low numbers.

This figure is very smallcompared to the number of potential candidates for transplantation: allof the 100,000 people suffering from type I diabetes and most of the 2 million patients with type II diabetes.

Sufferers from Type I diabetes are unable to produce insulin to control their blood glucose and have traditionally had to inject themselves with insulin several times a day.

Almost all patients with the “stiff-man-syndrome” in addition have autoantibodies against islet cells of the pancreas so that the “stiffman-syndrome” is often accompanied by a type I diabetes mellitus.

The functional relevance of GAD as an autoantigen in the “stiff-man-syndrome” as well as in type I diabetes mellitus was deduced from these observations.

Almost all patients with the "stiff-man-syndrome" in addition have autoantibodies against islet cells of the pancreas so that the "stiff-man-syndrome" is often accompanied by a type I diabetes mellitus.

The functional relevance of GAD as an autoantigen in the "stiff-man-syndrome" as well as in type I diabetes mellitus was deduced from these observations.

This shows that the antibodies according to the present invention are not only found in the blood of the particular donor from whose blood they were obtained, but are found generally in diabetic sera and that these antibodies have a general relevance for type I diabetes mellitus.

The present invention relates to 1-(4-hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine, various derivatives thereof, processes for the preparation of these compounds and their use as active ingredients in medicaments, mainly for the treatment of rheumatic disorders, in particular the forms which have a severe course, such as chronic graft-versus-host diseases which it has hitherto been hardly possible to treat, and of autoimmune diseases mediated by immune complexes, such as, for example, systemic lupus erythematosus, immune complex glomerulonephritis and type I diabetes.

Further, it is preferable if the autoimmune disease is selected from the group consisting of: type I diabetes mellitus, rheumatoid arthritis, multiple sclerosis, chronic gastritis, Crohn's disease, Basedow disease, Bechterew disease, psoriasis, myasthenia gravis, autoimmune hepatitis, APECED, Chrug-Strauss syndrome, ulcerative colitis, glomerulonephritis, Guillain-Barré syndrome, Hashimoto thyroiditis, lichen sclerosus, systemic lupus erythematodes, PANDAS, rheumatic fever, sarcoidosis, Sjörgren syndrome, Stiff-Man syndrome, scleroderma, Wegener's granulomatosis, vitiligo, autoimmune enteropathy, Goodpasture syndrome, dermatomyositis, polymyositis, autoimmune allergy, asthma and autoimmune reaction after organ transplantations.

Further, on the basis of a murine model of type I diabetes mellitus, the inventors were able to show that the onset of an autoimmune disease can be prevented by the treatment with the hIL-2 mutein according to the invention.

Clinical, epidemiological, and experimental data suggest that infections can sometimes trigger or exacerbate autoimmune diseases such as multiple sclerosis, type I diabetes, or rheumatoid arthritis.