Translation of "Signaling cascade" in German

Analysis of the ERK-activating signaling cascade showed LTA-induced phosphorylation of ERK-1, MEK1/2 and c-Raf.

An inhibition of the TNFR1 signaling cascade, therefore, is used today, for instance, for the treatment of inflammatory autoimmune diseases such as psoriasis.

Insulin activates insulin receptors and therewith a complex cell signaling cascade which results in increased glucose uptake into the cells.

In 1992, in search of the molecular causes of liver cancer, he and his research group were able to show that the X gene of the hepatitis B virus activates a signaling cascade in the liver cell that is also responsible for the development of cancer Chemicals is responsible.

The result of the mathematical modelling of the researchers was that the more rapid signaling cascade in B-cells can accelerate the output of the germinal centre by 24 hours and can clearly increase the total amount of antibody produced.

These proteins are produced in the germarium's anterior, where they bind to receptors on the GSCs and trigger a signaling cascade in GSCs, which culminates in the repression of a gene called bag of marbles (bam).

Interleukin-1-receptor antagonist (IL-1Ra) binds to the same receptors on the cell surface as interleukin-1 (IL-1), but does not trigger the signaling cascade normally caused by IL-1Ra binding.

The use according to the invention of the combination leads to an induction of the endogenous kinase inhibitor p16 Ink4a, by means of which the cell cycle-regulating retinoblastoma (Rb) is hypophosphorylated, and thus a signaling cascade is initiated that arrests the cell cycle.

Thereby, tumors can also be treated and transferred into the permanent quiescent state, wherein, by viral gene modifications or so-called “tumor driver” mutations exactly this signaling cascade is disturbed.

Disturbances and mutations in the area of the p53 or Rb signaling cascade will lead to an uncontrolled cell proliferation and furthermore in the long term to malignant tumors.

Activation of specific receptors initiates an intracellular signaling cascade which ultimately leads to cell proliferation and survival.

Presence of endotoxins in the blood stream causes a triggering of the signaling cascade and can lead to endotoxic shock.

Presence of endotoxins in the blood stream causes a triggering of the signaling cascade and may lead to endotoxic shock.

Binding induces a signaling cascade that ultimately results in synthesis of several interferon-stimulated genes, so-called ISGs ("interferon-stimulated genes").

On the other hand Silibinin prevents cardiomyogenesis through inhibition of the Ang II signaling pathway on the level of the ERK1/2, p38 and JNK signaling cascade.

In the nucleus, the signaling cascade results in activation of genes, that provide the proteins necessary for defense.

Binding induces a signaling cascade that ultimately results in synthesis of several interferon-stimulated genes, so-called ISGs (“interferon-stimulated genes”).

Potassium levels are known to effect cAMP signaling with the secretion of proteins producing a stepwise signaling cascade caused by exposure to the low potassium extracellular environment.

The structurally unique CNGK-channel is activated by small changes in intracellular cGMP concentration and initiates the chemotactic signaling cascade.

It separates from the receptor and the other subunits and activates further proteins.This is the first stage of a signaling cascade that culminates in the desired reaction.

Further, by the combined use of two substances that activate the STAT1 or the TNFR1 signaling pathway, a permanent growth arrest of ?-cancer cells can be achieved, whereas the activation either of the one or of the other signaling cascade can slow down the cell growth, but can by no means induce a complete and in particular permanent growth arrest persisting beyond the application of the cytokines Experimentally, it could be shown that the permanent growth arrest (the senescence) induced in vivo remained stable over a plurality of months—as long as the experiment could be continued for time and technical reasons.