Übersetzung für "Proteolytic processing" in Deutsch

Proteolytic processing of the Notch receptor is dependent on the activation of ligand.

Domain I is essential for the expression while domain II is required for correct proteolytic processing.

Pepsin is, as a matter of fact, preferred for the proteolytic processing steps described above, but other proteases, such as trypsin, are also suitable here.

The Picorna viruses, a family of significant viruses pathogenic to humans and animals, are for example totally dependent on proteolytic processing.

In the case of HIV I, it was possible to make a connection between the inhibitory effect of cerulenin and the inhibition in the proteolytic processing of the polyprotein of HIV I (Pal, R. et al., Proc.

This observation lead to the conclusion that the proteolytic processing at Y-G sites requires its own proteinase.

The DNA chain may be constructed so as to encode the desired sequence as a portion of a fusion peptide and if so, it may contain terminal sequences that encode amino acid residue sequences that serve as proteolytic processing sites, whereby the desired peptide may be proteolytically cleaved from the remainder of the fusion peptide.

Obviously, the proteolytic processing of gp160 to gp120 and gp41, which takes place in a Golgi's apparatus, also occurs in the same manner in the case of wild-type env and mutant env protein if the processing sequence is intact.

Starting at the N-terminus, this proteolytic processing generates peptides of 56 kDa, 44 kDa and 42 kDa molecular weight from the 58 kDa TdT which all still have the active centre.

My current research focusses on how proteolytic processing events on key proteins impact on neurodegenerative diseases such as rare and transmissible prion diseases or Alzheimer`s disease, the most frequent cause of dementia.

Protease inhibitors: they bind to the active centre of the viral protease, thus preventing the proteolytic processing of the gag and gag-pol precursor protein in its active viral subunits.

In addition to the molecular switch system based on the protein interaction-dependent recombinase activity, the invention also relates to a further switch system at the molecular level which is based on the activity of a protease, provided in a protein interaction-dependent manner, or on coupling of a protease activity with a reporter activated by proteolytic processing.

Amyloid ?(1-42) protein is a polypeptide having 42 amino acids which is derived from the amyloid precursor protein (APP) by proteolytic processing.

Therefore, the accessibility of proteolytic processing sites in the antigen, the stability of the resulting peptides in the lysosomes and the affinities of the peptides for MHC molecules are determining factors for the immunogenicity of a specific epitope.

However, proteolytic processing, for example by plasmin, plasma transglutaminase or thrombospondin, is certainly necessary (Munger (1997) Kindey Int 51: 1376-1382).

Viruses with complex transcription use ribosomal frameshifting and proteolytic processing to produce multiple proteins from the same gene sequences.

Subsequently, the proteolytic process was followed through the addition of the peptide-substrate Suc-LLVY-AMC.

A proteolytic process results in fibrinogen degradation fragments which are smaller than fibrinogen and may have low molecular weights.

The pharmacokinetic behaviour of MACI is related to the resorption of the collagen membrane, a proteolytic process performed by cells in the vicinity of the defects.

Additionally, it was found that the major quantity of proteases in these preparations arises from the enzymatic transpeptidation of porcine insulin to human insulin ester/ether or from proteolytic processes for the cleavage of insulin-like precursors.

The activity of the L(+)-tartrate dehydrogenase is also maintained during the course of a comparatively long stationary phase so that proteolytic processes can be excluded.

They comprise, for example, acetylations, acylations, ADP ribosylations, amidations, covalent linkages with flavins, haem portions, nucleotides or nucleotide derivatives, lipids or lipid derivatives or phosphatidylinositol, cyclizations, formation of disulphide bridges, demethylations, cystine formations, formylations, gamma-carboxylations, glycosylations, hydroxylations, iodinations, methylations, myristoylations, oxidations, proteolytic processings, phosphorylations, selenoylations and tRNA-mediated additions of amino acids.

They encompass for example acetylations, acylations, ADP ribosylations, amidations, covalent linkages to flavins, haeme moieties, nucleotides or nucleotide derivatives, lipids or lipid derivatives or phosphatidylinositol, cyclizations, the formation of disulphide bridges, demethylations, the formation of cystine, formylations, gamma-carboxylations, glycosylations, hydroxylations iodinations, methylations, myristoylations, oxidations, proteolytic processings, phosphorylations, selenoylations and tRNA-mediated additions of amino acids.

For example, they encompass acetylations, acylations, ADP ribosylations, amidations, covalent linkages to flavins, haem moieties, nucleotides or nucleotide derivatives, lipids or lipid derivatives or phosphatidylinositol, cyclizations, disulphide bridge formations, demethylations, cystine formations, formylations, gamma-carboxylations, glycosylations, hydroxylations, iodinations, methylations, myristoylations, oxidations, proteolytic processings, phosphorylations, selenoylations and tRNA-mediated amino acid additions.

Preferentially, the composition according to the invention can contain additional substances for stabilization, such as, for example, antioxidants or reducing agents for the prevention of oxidative degradation, proteinase inhibitors for the prevention of proteolytic processes, particularly preferably aprotinin, chelating agents for the exclusion of heavy metal ions or bacteriostatics and fungicides for the avoidance of microbial growth, particularly preferably sodium azide.

However, disadvantages of eukaryontic expression systems are in particular possible hyperglycosylations (Grobe et al., 1999, Eur J Biochem 263: 33-40), proteolytic degradation processes and comparatively small product yields (Glover and Hames (eds.