Übersetzung für "Murine model" in Deutsch

In the murine skin transplant model it could be shown that a monoclonal, immunosuppressive antibody, that was humanized by genetic engineering methods achieves a survival time of transplants against murine T lymphocytes, i.e., prolonged by a multitude, when its application was preceded by one or more injections of a monoclonal immunosuppressive mouse antibody.

Monotherapy with lefitolimod resulted in a clear beneficial modulation of the TME together with a reduced tumor growth in a murine colorectal cancer model.

After experimental induction of the antigen in tumor endothelial cells, an antivascular therapy could be demonstrated by administering the antibody in a murine neuroblastoma model (14).

Effects of suppressing CK2 biosynthesis and the resulting low CK2 concentration in the tumour tissue has, for example, been investigated in the murine xenograft model of the prostate carcinoma (Slaton et al., 2004).

As could be demonstrated in the syngeneic (autologous) murine tumor model also other factors play an important role for a particularly successful induction of the immunity.

Thus, in experiments using the murine tumor model it has been demonstrated that the desired successful immunization is not achieved if the number of tumor cells is too low.

The development of a long-lasting immune protection against the tumor by means of bsabs was examined in a murine autologous tumor model.

An in-vivo experiment is also described, in which the efficacy of the treatment was tested in a murine colon carcinoma model.

The anti-inflammatory effect of the inventive compounds of the general formula (I) was examined in a further murine arthritis model.

The translation of these results into an experimental murine model verified the epidemiological hypothesis of a prenatal programming and, in addition, points out to the underlying mechanisms of setting the direction in the maturation of the immune system.

To trace TLR9's movements within the cell, the researchers developed a murine model, in which mice produced a color-labeled version of the protein.

Carrier et al 18 in 1995 demonstrated that in a murine model with bilateral section of the cavernous nerve there was a significant reduction in NO synthesis as fast as 3 weeks after injury and that these reductions were maintained at 6 months.

Using the ovalbumin-induced murine asthma as model, we will then clarify whether the H4-receptor plays the anti-inflammatory role postuled by our group and which cell types (dendritic cells, T cell subpopulations, mast cells) are involved.

Regarding EnanDIM(R), the follow-up molecules to lefitolimod, MOLOGEN has also carried out initial pre-clinical examinations in combination with checkpoint inhibitors and presented initial results at the ASCO Clinical Immuno-Oncology Symposium (SITC) in February 2017: The pre-clinical data from a murine colorectal cancer model revealed that EnanDIM(R) can significantly improve the anti-tumor effect of an anti-PD-1 checkpoint inhibitor in comparison with the monotherapeutic approach, thereby prolonging survival.

For the evaluation of the tumor enrichment and the tissue distribution in experimental animals, [18 F]-4-glutamic acid was tested in a murine F9 teratocarcinoma model in NMRI nude mice and a murine B16F1 melanoma model in C57BI6 mice.

In murine syngeneic tumour models, dual blockade of PD-1 and CTLA-4 resulted in synergistic anti-tumour activity.

Two major metabolites have been identified in murine models and humans, i.e. CGP62221 and CGP52421.

The anti-tumour activity of the inventive compounds of the general formula (I) is studied in murine xenotransplantation models.

Blockade of PD-L1 signaling has been shown in murine models of pregnancy to disrupt tolerance to the foetus and to result in an increase in foetal loss.

However, in murine models of pregnancy, blockade of PD-L1 signalling has been shown to disrupt tolerance to the foetus and to result in an increased foetal loss (see section 5.3).

Blockade of PD-L1 signalling has been shown in murine models of pregnancy to disrupt tolerance to the foetus and to result in an increase in foetal loss.

Blockade of PD-L1 signalling has been shown in murine models of pregnancy to disrupt tolerance to the foetus and to increase foetal loss.

The gold standard for exploring experimental arthritis in murine models is histopathological investigation, which means that animals have to be sacrificed to assess joint inflammation and bone destruction.

In previous studies it was already shown that in murine tumor models monotherapy with EnanDIM(R) candidates resultedin a beneficial modulation of the tumor microenvironment (TME) translating into remarkable anti-tumor effects with remarkably increased survival rates.

The first reported isolation of human embryonic stem cell lines (hESCs) has shifted the focus away from murine models and allowed exploration of their therapeutic implications.

Studies of murine models have shown that L-selectin is crucial to mediating leukocyte rolling following surgical trauma and is also required for the recruitment of neutrophils, following inflammation.

The data showed that lefitolimod can significantly improve the anti-tumor effect of checkpoint inhibitors, particularly anti-PD-1 and anti-PD-L1 antibodies, and thus prolong survival in murine tumor models.