Übersetzung für "Intercurrent illness" in Deutsch

Intercurrent illness requires intensified metabolic monitoring.

Once the intercurrent illness episode is over, patients can return to the normal maintenance dose.

During intercurrent illness, there should be high awareness of the risk of developing acute adrenal insufficiency.

This regimen has been documented in over 300 intercurrent illness episodes within the clinical study programme.

During intercurrent respiratory illness close monitoring of blood glucose concentrations and dose adjustment may be required on an individual basis (see section 4.2).

During intercurrent respiratory illness (e.g. bronchitis, upper respiratory tract infections) close monitoring of blood glucose concentrations and dose adjustment may be required on an individual

These include: - change in the injection area, - improved insulin sensitivity (e.g., by removal of stress factors), - unaccustomed, increased or prolonged physical activity, - intercurrent illness (e.g. vomiting, diarrhoea), - inadequate food intake, - missed meals, - alcohol consumption, - certain uncompensated endocrine disorders, (e.g. in hypothyroidism and in anterior pituitary or adrenocortical insufficiency), - concomitant treatment with certain other medicinal products.

However, several reports of hypoglycaemia with related hypoglycaemic seizure were reported during the compassionate use program and in literature, especially in case of fasting period during intercurrent illness (see section

During transient illnesses such as low grade infection, fever of any aetiology, stressful situations such as minor surgical procedures, the daily replacement dose must be increased temporarily, see section 4.2, ‘Use in intercurrent illness'.

There have been cases of patients discontinuing Jakavi who sustained more severe events, particularly in the presence of acute intercurrent illness.

Symptoms of vomiting, nausea, headache, somnolence, confusion, or sleepiness in the absence of high ammonia or intercurrent illness may be signs of phenylacetic acid (PAA) toxicity (see section 4.4, PAA toxicity).

However, several reports of hypoglycaemia with related hypoglycaemic seizure were reported during the compassionate use program and in literature, especially in case of fasting period during intercurrent illness (see section 4.4).

In situations when the body is exposed to excessive physical and/or mental stress, patients may need additional substitution of immediate release hydrocortisone tablets especially in the afternoon/evening, see also section ‘Use in intercurrent illness’ where other ways of temporarily increasing the dose of hydrocortisone is described.

Intercurrent illness as well as adverse events noted by the patient should be recorded and any change in libido registered.

During transient illnesses such as low grade infection, fever of any aetiology, stressful situations such as minor surgical procedures, the daily replacement dose must be increased temporarily, see section 4.2, 'Use in intercurrent illness'.

In situations when the body is exposed to excessive physical and/or mental stress, patients may need additional substitution of immediate release hydrocortisone tablets especially in the afternoon/evening, see also section 'Use in intercurrent illness' where other ways of temporarily increasing the dose of hydrocortisone is described.