Übersetzung für "Xenogenic" in Deutsch

We place a mixture of autologous bone and xenogenic bone replacement material in between.

In accordance with the invention cortical fixation elements can be used which are produced from allogenic or xenogenic bone matter.

Nowadays sophisticated technologies are used to minimise such risks in the case of so-called xenogenic bone replacement materials.

In a preferred embodiment, the pericardium is xenogenic, in particular of bovine, procine or equine origin.

When using an allogenic or xenogenic tissue matrix, the at least one vessel branch is preferably provided with endothelial cells.

10 ad hoc groups will meet in 2002 The ad hoc groups concern paediatrics, oncology, anti-HIV medicines, comparability of biotechnology products, pharmacogenetics, xenogenic cells, gene therapy, anti-bioresistance, vaccines and biological threats

This is particularly important in the context of the emergence of new therapies, such as gene therapy and associated cell therapies, and xenogenic somatic therapy.

Consequently, alongside the considerations linked to the experience of six years of implementation of the centralised procedure and the operating of the Agency, account should also be taken of the current progress of applied sciences in the pharmaceutical field (particularly in the field of biotechnology) and also probable future developments (for example, the increased development of the technologies underlying gene therapy, current developments in pharmacogenomics and xenogenic somatic therapy trials).

The emergence of new fields of research (pharmacogenomics, gene therapy and cell therapy, including xenogenic somatic therapy, etc.) together with the burgeoning of small and medium-sized businesses in these fields makes it essential to create a genuine partnership between the industry and the authority responsible for assessing future medicinal products, respecting the areas of competence of each party.

It is obvious that conventional expression constructs lead not only to the expression of the desired gene, but also to the biosynthesis of xenogenic proteins, even if their prokaryotic promoters show very low activity in mammalian cells.

But not only the xenogenic nature of the hybrid cell contributes to the mediation of the achieved anti-tumor effect, since a hybrid cell secreting a bsAb having a defective APC binding arm is not able to induce a complete tumor protection.

Nevertheless, by its synergistic action with the mechanism of the specific idiotype redirection the xenogenic portion seems to be of importance.

In the case of allogenic and xenogenic transplantation of biological parts however, the problem arises of immunological incompatibility, which leads to rejection by the living organism with respect to the transplant and for the most part constrains the receiver to lifelong intake of immunosuppressive substances with concurrent damaging side effects.

As human liver cells are not available in sufficient quantity and can be multiplied only inadequately in culture, either hepatoma cell lines or xenogenic hepatocytes from pigs were used.

The invention relates to a preserved, deantigenated tissue matrix of an animal or human hollow organ, e.g. of a blood vessel, of the ureter or urinary bladder, which matrix is autologous, allogenic or xenogenic with respect to a recipient and whose biomechanical properties are not or only slightly impaired by such preservation, which does not include any infectious particles from the donor and is excellently suited for coating with recipient endothelial, epithelial, fibroblast, or muscle cells in order to produce autologous grafts for said recipient.

Non-vital xenogenic grafts, such as chemically modified cardiac valves of pigs, have been used successfully in cardiac surgery for a long time.

The autologous cells required for colonization (of the tissue matrix produced according to the invention, which is allogenic or xenogenic with respect to the recipient) are collected from tissue biopsy material having structural and metabolic properties identical or similar to those of the tissue structure to be replaced.

In principle, we differentiate between hydroxyapatites that were synthesized from the minerals calcium and phosphate and hydroxyapatites of allogenic or xenogenic origin.

Moreover, the extracellular protein can also be xenogenic, in particular of bovine, porcine or equine origin.

Sentence 1 shall not apply to: 1. advanced therapy medicinal products and xenogenic medicinal products, in so far as these are or contain living somatic cells which have been genetically modified or whose biological properties have been changed using other procedures, as well as 2. medicinal products intended for clinical trials in so far as it is not merely a case of reconstitution.

Groups of animals that are used for harvesting xenogenic hydroxyapatite must be kept isolated under strict guidelines.

As a result of the above-mentioned multiplicity of problems associated with the use of autogenous bone, donor bone or xenogenic bone, research into alternatives in the form of synthetic biomaterials able to replace or supplement the use of natural bone materials was begun at an early stage.

Furthermore, the biologically degradable composite material can be characterised in that the at least one organic component (c) is selected from gelatin, collagen, glycosaminoglycan, hyaluronan, sodium hyaluronate, calcium hyaluronate, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, starch, dextran, hydroxyethyl starch, alginate, polyethylene glycol, albumin, chitosan, organically processed or demineralised allogenic or xenogenic bone, synthetic polypeptide, parathormone, osteogenic protein, or a combination thereof.

The biological materials are preferably of xenogenic origin, in particular of bovine, porcine and/or equine origin.