Übersetzung für "Adenyl" in Deutsch

Binding to these receptors inhibits adenyl cyclase activity which lowers cyclic adenosine monophosphate (cAMP).

The pharmacological effects of beta2-adrenoceptor agonists are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cyclic monophosphate).

The pharmacological effects of beta2-adrenoceptor agonists are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3’, 5’-adenosine monophosphate (cyclic monophosphate).

Especially preferred is the reaction with succinic acid anhydride of nucleosides of the formula V protected in the 5'-position and optionally in the base moiety, in which R1 represents a protecting group that can be removed by acid, such as a triarylmethyl protecting group, for example a 4-methoxytrityl group or a 4,4'-dimethoxytrityl group, or a tri-lower alkylsilyl protecting group, for example a tert.-butyldimethylsilyl group, and in which B represents an optionally protected base selected from the group comprising thymyl, cytosyl, adenyl and guanyl, optionally in the presence of bases, such as pyridine, triethylamine or dimethylaminopyridine, followed by reaction with aminomethylated polystyrene that is crosslinked by from 0.5 to 2% divinylbenzene, with the aid of reagents that activate the carboxylic acid radical, preferably N-hydroxy succinimide, or p-nitrophenol and dehydrating agents, such as carbodiimides, for example dicyclohexyl carbodiimide (scheme 1).

At this time, however, the levels of ADP and AMP does not rise greatly (allergic myocarditis), and the total content of adenyl nucleotides is still low (toxic-allergic myocarditis) or it increases slightly (adrenaline-mediated heart disease, Tabl. 4), or even it returns to the normal (allergic myocarditis, Tabl. 3).

The rise in ADP and AMP becomes so significant that the total adenyl nucleotides will return to the normal, or even their level will be above-normal.

This may be attributed to the fact that inosine has a pronounced effect on de novo adenyl nucleoide synthesis.

The degree and the nature of the action of the preparations in question on the oxygene and energy deficiency-associated conditions were judged from the levels of ATP, ADP, AMP, CP, the ATP/ADP ratio and the bioenergetic potential of adenyl nucleotides.

With a 10-day TAM, Energostim to be administered for 5-day period exibits a pronounced meditative effect, thereby giving rise to a complete normalization of the levels of adenyl nucleotides and their total content as well as the energetic potential and CP level of the system (Tabl. 8).

The values given in Table III show that the compounds according to the invention are substantially more effective than ISMN, whereby the adenyl derivative of 1.4;3.6-dianhydro-iditol mononitrate (compound according to Example 1c/2c) is even more effective than ISDN.

In an analogous manner, the unsubstituted adenyl derivative can be obtained by reaction of the 6-chloro- or 6-methylmercaptopurinyl derivative with ammonia.