Übersetzung für "Tuftsin" in Deutsch

Preferred covalently bonded adjuvants of the invention include short-chain peptides, particularly preferably tuftsin or oval-bumin.

This synthetic variant of immunomodulatory tetrapeptide tuftsin possesses anxiolytic properties because of its mimic nature.

It is a synthetic analogue of a human tetrapeptide tuftsin.

Selank is a synthetic derivative of the human body's naturally produced tetrapeptide Tuftsin.

Postin (Lys-Pro-Pro-Arg) is the N-terminal tetrapeptide of cystatin C and an antagonist of tuftsin.

Neuropeptide Selank is a synthetic derivative of the human body's naturally produced tetrapeptide Tuftsin.

Preferred covalently bonded adjuvants of the invention include short-chain peptides, particularly preferably tuftsin or ovalbumin.

Rigin (glycyl-L-glutaminyl-L-prolyl-L-arginine) is a tetrapeptide with functions similar to those of tuftsin.

Selank is a synthetic analogue of the immunomodulatory peptide tuftsin, it mimics many of its effects.

These preparations, which together with IGAM exhibit a synergistic effect, are those containing antibiotics, tuftsin and other oligopeptides consisting of immunoglobulin chains, fibronectin, interferons, a1 -antitrypsin, antithrombin and lysozyme.

44% of the animals were protected by the administration of immunoglobulin preparation, but 67% of the animals that received the combination of immunoglobulin and tuftsin were protected.

In an experiment identical to the one with tuftsin, mice (21 animals per group) were infected with Salomonella typhimurium (i.p.)

In experiments identical to those with tuftsin and cefamandole, it was observed that a synergistic effect occurs when IGAM and lysozyme are used jointly.

Tuftsin stimulates a number of immunological processes, including the activation of immunocompetent cells (increase of phagocytosis) and thereby also the accelerated destruction of the microorganisms that have invaded the organism.

The phagocytosis (takeup of the microorganisms into the immunocompetent cells and the subsequent destruction) is stimulated by tuftsin.

Then an aquerous solution containing 0.5 mg of tuftsin dissolved in 0.5 ml of IGAM solution, was applied intravenously.

After 24 hours, all animals in an untreated control group had died, and likewise all animals that received only tuftsin.

In an experiment identical to the test with tuftsin, animals infected with Pseudomonas aeruginosa were treated with a mixture of fibronectin (250 units/animal) and 25 mg of IGAM.

The linear peptide tuftsin, which is not one of the peptide antibiotics, has a macrophagic stimulating effect so that the pangocytosis and the antineoplastic effects of this tetrapeptide have been detected in vitro and in vivo.

With the exception of the tuftsin these are poorly compatible antibiotics, this applying in particular to the polymixins which can either be used only for local treatment or from the systematic point of view function without exception as "reserve" antibiotics.

Whereas tyrothrocin consists of a mixture of basic tyrocidines (80% A, 20% B-E) and linear gramicidins (D) which have a neutral pK and are synthesized by Bacillus subtilis, tuftsin is a natural activator of phagocytic cells and is thus of eukaryotic origin.

In particular, tuftsin activates the macrophages and thus not only intervenes in immunologically controlled inflammation processes but also in antineoplastic and immune-restorative processes.

For these specifically included active substances, in particular the linear tyrocidine and the cyclic tyrocidine (A-E) as well as the tuftsin and its analogs, gramicidin (D and S) and the polymyxins, in addition typical NMR signals are obtained which are characteristic of the secondary or monomer structure of these cyclic and linear peptides in the hydrophobic micellar core.

In addition, active antibiotic peptides or peptide analogs may be stirred in, such as linear or cyclic gramidin or linear or cyclic tyrocidine or tuftsin, which are dissolved in micellar manner, possible subjected to sonication.

Suitable adjuvants for the vaccination of animals include but are not limited to Freund's complete or incomplete adjuvant (not suitable for human or livestock use), Adjuvant 65 (containing peanut oil, mannide monooleate and aluminum monostearate), mineral gels such as aluminum hydroxide, aluminum phosphate and alum, surfactants such as hexadecylamine, octadecylamine, lysolecithin, dimethyldioctadecylammonium bromide, N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)propanediamine, methoxyhexadecylglycerol and pluronic polyols, polyanions such as pyran, dextran sulfate, polyIC, polyacrylic acid and carbopol, peptides and amine acids such as muramyl dipeptide, dimethylglycine, tuftsin and oil emulsions.

In contrast, suitable tyrocidine (A-E) and cyclic gramicidin (S) as well as tuftsin do not effect hemolysis, as has surprisingly been found.

An object of the present invention is to provide pharmaceutical preparations which contain as active substances linear and cyclic peptide antibiotics (peptide analogs) in particular for tyrocidines A-E, gramacidins (linear or cyclic) and tuftsin, these active substances being contained in stable and monomeric form, being stable in aqueous solution and remaining monomeric, and can develop their pharmacodynamic effect under physiological pH conditions (pH 7.0 to 8.0) and with which said active substances are liberated at the location of the pathological process as rapidly and completely as possible.

In addition, active antibiotic peptides or peptide analogs may be stirred in, such as linear or cyclic gramidin or linear or cyclic tyrocidine or tuftsin, which are dissolved in micellar manner, possibly subjected to sonication.

This applies in particular to the derivatives of cyclic tyrocidine (A-E), of gramecidin and their analogs and of the immunologically effective tuftsin and its analogs.