Übersetzung für "Titin" in Deutsch

Due to its large size titin is not easy to modify.

Patients with a changed titin develop heart conditions associated with a limited cardiac pumping function.

Elastic myofilaments are composed of a springy form of anchoring protein known as titin .

As the largest known protein, titin also has the longest IUPAC name of a protein.

Located beside the Bassin de Thau, the establishment "Chez Titin" invites you to taste its production of oysters, mussels cooked in a traditional way.

These titin-deficient animals are the basis for development of medicamentous, cellular and genetic therapies for heart and muscle weakness.

The interaction between titin and a-actinin stabilizes all muscles when they are stretched – regardless of whether during breathing, walking, grasping or laughing.

And yet, the protein link is the key to understanding: In muscles, each titin strand is held by up to seven a-actinin proteins.

Researchers at the Technical University of Munich (TUM) have now measured the forces acting between the building blocks titin and a-actinin which stabilize the muscle.

The largest known protein, titin, which is essential for muscle function, consists of more than 27,000 amino acids, for example.

The interaction between titin and --actinin stabilizes all muscles when they are stretched - regardless of whether during breathing, walking, grasping or laughing.

Dr Gotthardt will study the function of titin in the detection and transmission of mechanical signals (stretching of muscles) at the Max Delbrück Center for Molecular Medicine in Berlin-Buch.

And yet, the protein link is the key to understanding: In muscles, each titin strand is held by up to seven --actinin proteins.

If PIP2 is available, the connection opens and renders the domain available to bind to another muscle protein – titin.

Researchers at the Technical University of Munich (TUM) have now measured the forces acting between the building blocks titin and --actinin which stabilize the muscle.

Due to its molecular structure titin can expand like a spring and therefore enables the effective functioning of muscle cells.

It is homologous to palladin and titin in the two C-terminal lg-domains and also to palladin in its unique serine-rich N-terminal region.

Dr Gotthardt has developed mouse models for modification of titin in the live organism and its structural as well as functional analysis.

In hypertrophic cardiomyopathy, disease alleles encode mainly sarcomere proteins like actin, myosin heavy and light chains, myosin-binding protein C, troponin, tropomyosin or titin.

His most important scientific achievement is the discovery of the modular unfolding of titin using a method he developed, known as single-molecule force spectroscopy.

TP B03 investigates segments of the giant elastic sarcomere protein titin and their interaction with structural and signaling proteins as potential mechanosensor complexes at elevated loads.

The trick here – as revealed by the structural data from this FWF project – is that the neck region of the a-actinin is similar in structure to titin.