Übersetzung für "Entschützung" in Englisch

The, amino alcohol 12 was obtained by deprotecting the cyclohexenone unit 11 .

This step is referred to as deprotection.

Alternatively, also first a deprotection and then a purification of the product can take place.

After stirring for one hour, thin layer chromatography shows complete deprotection.

Deprotection of 4b takes place as described under 3a.

For deprotection, the compound F-2 is reacted with tetrabutylammonium fluoride in tetrahydrofuran.

This crude product was used without further purification for deprotection to 2-decyn-1-ol.

The removal of t-butyl ester protecting groups with elimination thereof as isobutene is likewise described in the literature.

This avoids the necessity of a complicated and, for the customer, highly risky process of deprotecting the RNA oligonucleotides.

In addition, selective deprotection is possible through the presence of different protecting groups (orthogonal protecting groups).

The deprotection is effected hydrolytically, for example by contact with water or moisture, especially air humidity.

For further details, reference is also made to the deprotection of VI to give compound II.

The title compound was prepared by coupling Intermediate L8 with 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-beta-alaninate and subsequent deprotection with TFA.

The subsequent splitting-off of protecting groups can be carried out according to conventional methods for example by reductive deprotection with Pd/active charcoal and hydrogen or by treatment with trifluoroacetic acid.

After washing back the organic phase with 0.1N hydrochloric acid and then with NaCl-saturated water the protected final compound is obtained which can be employed for deprotection without further purification.

However, these groups were also deprotected with ammonia (Kume et al., see above).

Preferably, the deprotection takes place in the presence of a 0.1 to 5 M solution of DBU at from 0 to 70° C. for from 0.1 to 16 h, more preferably in the presence of a 0.3 to 3 M solution of DBU at from 10 to 40° C. for from 0.1 to 2 h, and most preferably in the presence of a 0.5 to 2.5 M solution of DBU at from 20 to 30° C. for from 0.2 to 1.5 h.

The subsequent step of this process variant comprises the reduction of the ester group —COOAlkyl of the pentadienoic acid ester (XIV) as well as the deprotection of the likewise present trimethylsilyloxy group.

Addition of these monomers onto an OH or NH containing initiator molecule and removal of the protection on the OH groups gives polyurethane polyols which grow into dendritic structures by divergent (shell-like) buildup.

The process as claimed in claim 1, wherein the protected oligonucleotide, which is bound to the solid support, is deprotected at a temperature ranging from 0 to 70° C. and for a time ranging from 0.1 to 16 h with a 0.1 to 5 M solution of diazabicyclo5.4.0!undec07-ene.

The process as claimed in claim 1, wherein the protected oligonucleotide, which is bound to the solid support, is deprotected at a temperature ranging from 10 to 40° C. and for a time ranging from 0.1 to 2 h with a 0.3 to 3 M solution of diazabicyclo5.4.0!undec07-ene.

The process as claimed in claim 1, wherein the protected oligonucleotide, which is bound to the solid support, is deprotected at a temperature ranging from 20 to 30° C. and for a time ranging from 0.2 to 1.5 h with a 0.5 to 2.5 M solution of diazabicyclo5.4.0!undec07-ene.

While the synthesis of the oligonucleotide on the solid support takes place very rapidly--approximately one hour is required for a 20 mer--and cleavage from the support is also complete within an hour, the final deprotection of the oligonucleotide remains a problem.

The invention additionally provides a process for preparing crosslinked polyacrylates, which involves first protecting the polymers to be crosslinked by introducing tert-butoxycarbonyl groups, and in which crosslinking takes place only after the deprotection, by thermal treatment of the now deprotected polyacrylates.

The chemical reaction whose consequence is to convert nonpolar into polar PSA compositions on the backing is a deprotection of the tert-butyl acrylate to give the free carboxylic acid, in the presence of protons, and has already been known for a long time [Loev, Chem.

To test the stability, the following uridine derivatives were incubated in 0.05N HCl/MeOH (1:2), 30 mmolar solution, 20° C., pH 2.0 (Table 1) or in 80% acetic acid, molar solution, 20° C. (Table 2) and the half-life for deprotection was determined: