Translation of "Feuchtgranulierung" in English

Additionally to fluid bed and wet granulation we also offer you a compaction process.

Also, it is an efficient wet granulator.

Granulation methods that may be used include in particular moist granulation, dry granulation and melt granulation, although other methods are not ruled out.

Granules may be produced by wet granulation, by dry granulation or compaction and by melt solidification granulation.

The polymers are, however, also suitable for use in wet granulation, fluidized-bed granulation or dry granulation.

Granulating can be conducted by wet granulation, preferably with water or aqueous solutions with dissolved binder.

In moist granulation, the powder mixture is processed with a liquid to a paste, from which the granules are formed, after drying, evaporation or solidification of the granulation liquid.

In wet granulation, for example, the lactose powder is premixed with component (C) in a suitable mixer, the solution of component (B) is poured in with further stirring, and the moist material is passed through a sieve and then dried.

The process according to claim 6, wherein step (b) is implemented as a wet granulation with a solvent or a solvent mixture, which dissolves at least a part of the polyelectrolytes without triggering a reaction between the metal-cation-releasing compound and polyelectrolytes, and which is removed after granulation.

The process according to any one of claims 6 to 7, wherein the solvents used for wet granulation provide polar properties.

The invention also relates to a process for successively mixing, moist-granulating and drying in the manufacture of solid pharmaceutical products, particularly pharmaceutical granules, in which the necessary mixing operations, moist-granulation and subsequent drying operation are carried out in one container and drying is effected using a combination of contact, vacuum, flushing air and infrared drying with the aid of an electrically heated ceramic infrared panel radiator mounted outside the dryer or an electrically heated quartz tube radiator.

By the term hydrogranulation a procedure is meant in which the active ingredient and/or the active ingredient mixture is granulated in an appropriate device, particularly in a mixer and/or a fluid bed granulator, during addition of the additional ingredients mentioned in the examples.

When the products, submitted to the spray-drying, the hydrogranulation and the consolidation, are coated with an appropriate polymer which is in the following examples the product Eudragit E12,5, then this is marked in the following quoted examples by indicating the above mentioned product.

Granules suitable for tabletting have hitherto been produced from the lyophilizate by subsequent moist granulation with polyvinylpyrrolidone as a binder and carboxymethylstarch as a filler, but water cannot be used as the granulating fluid and, instead, organic solvents, for example isopropanol, must be used.

In order to overcome these difficulties, celiprolol hydrochloride is processed at the present time to give compressible granules, for example by moist granulation using collidone as binder.

The novel intimate mixtures of the components (A), (B), and (C) are prepared by a conventional method, for example spray granulation, wet granulation or, preferably, spray drying.

For example, the acids and carbonates are granulated separately, preferably by moist granulation, during which the active ingredients are added to one of the granules.

Preferred granulation methods include moist granulation of the active ingredients with binders and subsequent drying in a fluidized bed and melt granulation.

In moist granulation, aqueous methods are preferred for environmental reasons and for reasons of occupational safety, but methods using organic solvents are also possible.

The most usual granulation technique is wet granulation, since this technique is subject to the least restrictions and most reliably gives rise to granules with favorable characteristics.

Wet granulation proceeds by moistening the powder mixture with solvents and/or solvent mixtures and/or solutions of binders and/or solutions of adhesives and is preferably carried out in mixers, fluidized beds or spray towers, it being possible for said mixers to be equipped, for example, with stirring and kneading tools.

In the case of moist granulation, for example, a granulation liquid, which preferably comprises a binder, is added to a powder mixture comprising the active compound together with the sugar alcohol and any further suitable adjuvants, the mixture is converted into aggregates of suitable size (granules) and subsequently dried.

In the case of wet granulation, the binder may be employed in the form of an aqueous or else organic solution comprising preferably 1 to 30% by weight of binder.

This makes it an ideal application for a hydrophilic matrix system, both in direct compression and in wet granulation.

It serves as a dry binder in the tableting process to improve compressibility, as a water-soluble binder or as a thickening and gelling agent in wet granulation.