Übersetzung für "Thiolase" in Deutsch

By decreasing fatty acid oxidation at the level of 3-ketoacyl coenzyme A thiolase, it favours glucose oxidation, which improves the use of the cells' energy reserves in the event of ischaemia.

Durch eine Verminderung der Fettsäureoxidation auf Ebene der 3-Ketoacyl-CoA-Thiolase begünstigt er die Glukoseoxidation, was die Nutzung der Energiereserven der Zellen im Falle einer Ischämie verbessert.

ELRC_2682 v1

In addition to the above-mentioned up-regulated proteins, however, down-regulated metabolic enzymes may also be used as a marker, in particular argininosuccinate synthetase, methylene tetrahydrofolate dehydrogenase, fructose-1,6-biophosphate aldolase, mitochondrial malate dehydrogenase, and mitochondrial acetoacetyl-CoA thiolase.

Neben den zuvor erwähnten hochregulierten Proteinen, können jedoch auch herunterregulierte metabolische Enzyme als Marker verwendet werden, insbesondere Argininosuccinatsynthetase, Methylentetrahydrofolatdehydrogenase, Fructose-1,6-Bisphosphataldolase, mitochondriale Malatdehydrogenase und mitochondriale Acetoacetyl-CoA-Thiolase.

EuroPat v2

The proteins are selected from the group of ER6Q, vimentin, actin alpha 1 skeletal muscle protein, hMFAP 4, tropomyosin, PTGES 2, amyloid P component, transgelin, calponin 1, homo sapiens p20 protein, 17 kDa myosin light chain, H chain H Igg B12, prolyl 4-hydroxylase, beta subunit methylenetetrahydrofolate dehydrogenase 1, PRO2619, aldehyde dehydrogenase 1, fibrinogen alpha chain preproprotein, fructose-bisphosphate aldolase B, argininosuccinate synthetase, Eefla2, AT P 5 A1, alpha-2 actin, regucalcin, serum albumin, mitochondrial malate dehydrogenase, mitochondrial acetoacetyl-CoA thiolase or in each case a partial sequence thereof.

Die Proteine sind ausgewählt aus der Gruppe ER60, Vimentin, Actin alpha 1 skeletales Muskelprotein, hMFAP 4, Tropomyosin, PTGES 2, Amyloid P-Komponente, Transgelin, Calponin 1, Homo sapiens p20 Protein, 17 kDa Myosin leichte Kette, H Chain H Igg B12, Prolyl 4-hydroxylase, beta subunit Methylentetrahydrofolatdehydrogenase 1, PR02619, Aldehyddehydrogenase 1, Fibrinogen alpha-Kette Preproprotein, Fructose-Bisphosphat-Aldolase B, Argininosuccinatsynthetase, Eefla2, ATP5A1, alpha-2-Actin, Regucalcin, Serumalbumin, mitochondriale Malatdehydrogenase, mitochondrialer Acetoacetyl-CoA-Thiolase oder jeweils eine Teilsequenz davon.

EuroPat v2

In the last step, a 3-ketoacyl-CoA thiolase, in the case of E. coli FadA, catalyzes the cleavage of the ketoacyl-CoA, with the result that acetyl-CoA and a CoA ester of the fatty acid that is two carbon atoms shorter compared to the starting molecule are released.

Im letzten Schritt katalysiert eine 3-Ketoacyl-CoA-Thiolase, im Falle von E. coli FadA, die Spaltung des Ketoacyl-CoA mit dem Ergebnis, dass Acetyl-CoA und ein im Vergleich zum Ausgangsmolekül um zwei Kohlenstoffatome verkürzter CoA-Ester der Fettsäure freigesetzt werden.

EuroPat v2

In the last step, a 3-ketoacyl-CoA thiolase, in the case of E. coli FadA, catalyses the cleavage of the ketoacyl-CoA with the result that acetyl-CoA and a CoA ester of the fatty acid shortened by two carbon atoms in comparison to the starting molecule are liberated.

EuroPat v2

Furthermore, the invention also relates to a corresponding method in which a decreased level of the proteins indicates the presence of an inflammation of the liver, in particular hepatic fibrosis and/or cirrhosis of the liver, in this case the proteins being selected from a group: methylene tetrahydrofolate dehydrogenase 1, PRO2619, aldehyde dehydrogenase 1, fibrinogen alpha-chain preproprotein, fructose-bisphosphate-aldolase B, argininosuccinate synthetase, EEF1A2, ATP5A1, alpha-2-actin, regucalcin, serum albumin, mitochondrial malate dehydrogenase, mitochondrial acetoacetyl-CoA thiolase.

Des Weiteren betrifft die Erfindung auch ein entsprechendes Verfahren bei dem ein verringerter Level der Proteine das Vorliegen einer Leberentzündung, insbesondere hepatische Fibrose und / oder Leberzirrhose, anzeigt, wobei in diesem Fall die Proteine ausgewählt sind aus einer Gruppe: Methylentetrahydrofolatdehydrogenase 1, PRO2619, Aldehyddehydrogenase 1, Fibrinogen alpha-Kette Preproprotein, Fructose-Bisphosphat-Aldolase B, Argininosuccinatsynthetase, Eef1a2, ATP5A1, alpha-2-Actin, Regucalcin, Serumalbumin, mitochondriale Malatdehydrogenase, mitochondriale Acetoacetyl-CoA-Thiolase.

EuroPat v2

In a preferred embodiment, the cell used according to the invention has a reduced activity, with respect to its wild type, of at least one enzyme which catalyses one of the reactions of the ?-oxidation of fatty acids, and preferably this is an enzyme from the group comprising fatty acid-CoA ligase, acyl-CoA dehydrogenase, 2,4-dienoyl-CoA reductase, enoyl-CoA hydratase and 3-ketoacyl-CoA thiolase, a fatty acid importer or variants thereof.

In einer bevorzugten Ausführungsform weist die erfindungsgemäß verwendete Zelle eine ihrem Wildtyp gegenüber verringerte Aktivität wenigstens eines Enzyms aufweist, das eine der Reaktionen der ?-Oxidation von Fettsäuren katalysiert, wobei es sich bevorzugt um ein Enzym aus der Gruppe handelt, die Fettsäure-CoA-Ligase, Acyl-CoA-Dehydrogenase, 2,4-Dienoyl-CoA-Reduktase, Enoyl-CoA-Hydratase and 3-Ketoacyl-CoA-Thiolase, einen Fettsäureimporter oder Varianten davon umfasst.

EuroPat v2

In a preferred embodiment, the cell used according to the invention has activity of at least one enzyme which catalyses one of the reactions of the ?-oxidation of fatty acids decreased compared to the wild type thereof, wherein this is preferably an enzyme from the group which comprises fatty acid-CoA ligase, Acyl-CoA dehydrogenase, 2,4-dienoyl-CoA reductase, enoyl-CoA hydratase and 3-ketoacyl-CoA thiolase, a fatty acid importer or variants thereof.

EuroPat v2